I've fallen in love with the paint program MyPaint. It's a multi-platform applictaion desinged around use with the drawing tablets such as the Wacom Bamboo and such. The Tablets have been supported in Linux for quite some time now, so setting up is as simple as plugging it in.
MyPaint has an endless canvas. This is great artistically speaking, but painful with my small 1 Gig of ram. It's time to expand that a little.
Traditionally I've worked by hand and scanned in my artwork. I like this better in some ways, I can separate the pencil from the ink and such. Plus I can carry my entire "Studio" where ever on a thumbdrive. Nice!
Having said that. I'm not turning my back on traditional art, just trying to streamline my creative process.